Age-related bone diseases such as osteoporosis and osteoarthritis affect hundreds of millions worldwide and place a massive economic burden on healthcare systems. Today’s therapies focus largely on slowing bone loss or managing pain, yet they often come with side effects and deliver poor long-term outcomes especially in older adults, who are most vulnerable. We are developing a first-in-class oral peptide therapy that simultaneously regenerates bone and restores the vascular microenvironment essential for long-term skeletal health. By leveraging natural physiological pathways, our approach offers a safe, regenerative alternative to current treatments, unlocking the potential for lasting improvements in mobility, healing, and quality of life.